Enhancing drug administration in <i>Drosophila melanogaster</i>: a method for using solid dispersions for improved solubility and bioavailability.

ABSTRACT: Drosophila melanogaster is a widely used model organism for diseases such as Parkinson's disease, Alzheimer's disease, obesity, and diabetes. However, compound administration-based toxicological and behavioural studies on Drosophila have been hindered by technical difficulties associated with inefficient administration of hydrophobic compounds. This study illustrates a general method to make and distribute PEG 8000-based solid dispersions for three hydrophobic compounds, distearoylglycerol (DSG) geldanamycin (GA) and RU486 to D. melanogaster. The solid dispersions were validated, in vitro, using nuclear magnetic resonance spectroscopy (NMR), to have a higher aqueous solubility. The study also describes three different methods to administer the solid dispersions: subcut

SUBMITTER: Cheku S 

PROVIDER: S-EPMC12036485 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature