Impact of Canadian Wildfire-Emitted Particulate Matter on THP-1 Lung Macrophage Health and Function.

ABSTRACT: Increasing frequency and intensity of climate-driven wildfires in recent years have resulted in increased human exposures to wildfire smoke and raised serious public health concerns. One potential risk of wildfire smoke exposure is the impairment that it may cause to lung macrophages, which serve as the first line of defense against inhaled pathogens and particles. Size-fractionated wildfire particulate matter (WFPM) collected in the New Jersey/New York metropolitan area during the June 2023 Canadian wildfire event was used to assess the effect on the health and function of THP-1 lung macrophages. Environmentally relevant in vitro WFPM doses were determined using established in vivo and in vitro dosimetry models. Exposure to WFPM_0.1-2.5 (0.1-2.5 μm) for 24 h caused a significant

SUBMITTER: Bazina L 

PROVIDER: S-EPMC12036631 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature