Cardiac output-guided haemodynamic therapy for patients undergoing major gastrointestinal surgery: OPTIMISE II randomised clinical trial.

ABSTRACT:

Objectives

To evaluate the clinical effectiveness and safety of a perioperative algorithm for cardiac output-guided haemodynamic therapy in patients undergoing major gastrointestinal surgery.

Design

Multicentre randomised controlled trial.

Setting

Surgical services of 55 hospitals worldwide.

Participants

2498 adults aged ≥65 years with an American Society of Anesthesiologists physical status classification of II or greater and undergoing major elective gastrointestinal surgery, recruited between January 2017 and September 2022.

Interventions

Participants were assigned to minimally invasive cardiac output-guided intravenous fluid therapy with low dose inotrope infusion during and four hours after surgery, or to usual care without cardiac output monitoring

SUBMITTER: OPTIMISE II Trial Group 

PROVIDER: S-EPMC12036648 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature