Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.

ABSTRACT: The medial prefrontal cortex (mPFC) has long been associated with economic and social decision-making in neuroimaging studies. Several debates question whether different ventral mPFC (vmPFC) and dorsal mPFC (dmPFC) regions have specific functions or whether there is a gradient supporting social and nonsocial cognition. Here, we tested an unusually large sample of rare participants with focal damage to the mPFC (N = 33), individuals with lesions elsewhere (N = 17), and healthy controls (N = 71) (total N = 121). Participants completed a temporal discounting task to estimate their baseline discounting preferences before learning the preferences of two other people, one who was more temporally impulsive and one more patient. We used Bayesian computational models to estimate baseline discountin

SUBMITTER: Su Z 

PROVIDER: S-EPMC12036846 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature