Extracellular vesicles play a central role in linking podocyte injury to mesangial activation in glomerular disease.

ABSTRACT: Background: Podocyte injury leading to proteinuria is the primary feature of a vast majority of glomerular diseases, while mesangial cell activation is the hallmark of glomerulosclerosis. Whether and how these two events are connected remains elusive. In this study, we investigated the role of extracellular vesicles (EVs) in linking podocyte injury to mesangial activation in glomerular disease. Methods: EVs were characterized by nanoparticle tracking analysis and electron microscopy. Differentially expressed proteins from podocyte-derived EVs were analyzed by protein microarray. The role and mechanism by which EVs-packaged sonic hedgehog (Shh) mediates mesangial cell activation were investigated in vitro and in vivo. Results: An increased production of EV

SUBMITTER: Liu Z 

PROVIDER: S-EPMC12036872 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature