Serine supplementation suppresses hypoxia-induced pathological retinal angiogenesis.

ABSTRACT: Rationale: Pathological retinal angiogenesis with irregular and fragile vessels (also termed neovascularization, a response to hypoxia and dysmetabolism) is a leading cause of vision loss in all age groups. This process is driven in part through the energy deficiency in retinal neurons. Sustaining neural retinal metabolism with adequate nutrient supply may help prevent vision-threatening neovascularization. Low circulating serine levels are associated with neovascularization in macular telangiectasia and altered serine/glycine metabolism has been suggested in retinopathy of prematurity. We here explored the role of serine metabolism in suppressing hypoxia-driven retinal neovascularization using oxygen-induced retinopathy (OIR) mouse model. Methods: We administered wild-type C

SUBMITTER: Yagi H 

PROVIDER: S-EPMC12036884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature