Biomimetic piezoelectric hydrogel system for energy metabolism reprogramming in spinal cord injury repair.

ABSTRACT: Rationale: Spinal cord injury (SCI) leads to limited regenerative capacity and severe energy deficiency in the injury microenvironment. This study aimed to develop a biomimetic piezoelectric hydrogel system that could recapitulate the native tissue microenvironment while enabling wireless physical regulation for SCI repair. Methods: A piezoelectric hydrogel was fabricated by integrating K_0.5Na_0.5NbO₃ (KNN) nanoparticles with porous decellularized spinal cord matrix gel (pDG). The hydrogel's effects on vascular endothelial cell migration, neural stem cell differentiation, and ATP synthesis were evaluated in vitro. RNA sequencing was performed to identify key regulatory pathways. The therapeutic efficacy was assessed in a rat model of spi

SUBMITTER: Shi G 

PROVIDER: S-EPMC12036890 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature