PD-1 activation mitigates lupus nephritis by suppressing hyperactive and heterogeneous PD-1⁺CD8⁺ T cells.

ABSTRACT: Rationale: Programmed cell death protein 1 (PD-1)-expressing CD8⁺ T cells are typically associated with exhaustion in cancer and infections, but their role in autoimmune diseases, particularly lupus nephritis (LN), remains less understood. Understanding the characteristics and functions of PD-1⁺CD8⁺ T cells in LN could help identify novel therapeutic strategies. Methods: We analyzed the abundance and phenotypes of PD-1⁺CD8⁺ T cells in LN patients and NZB/W F1 mice. Single-cell RNA sequencing (scRNA-seq) was used to delineate subsets and TCR clonal diversity in PD-1⁺CD8⁺ T cells in NZB/W F1 mice. The therapeutic efficacy of a PD-L1 Fc fusion protein on kidney pathology and proteinuria in NZB/W F1 mice

SUBMITTER: Deng J 

PROVIDER: S-EPMC12036892 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature