Activation of the Drosophila innate immune system accelerates growth in cooperation with oncogenic Ras.

ABSTRACT: Innate immunity in Drosophila acts as an organismal surveillance system for external stimuli or cellular fitness and triggers context-specific responses to fight infections and maintain tissue homeostasis. However, uncontrolled activation of innate immune pathways can be detrimental. In mammals, innate immune signaling is often overactivated in malignant cells and contributes to tumor progression. Drosophila tumor models have been instrumental in the discovery of interactions between pathways that promote tumorigenesis, but little is known about whether and how the Toll innate immune pathway interacts with oncogenes. Here we use a Drosophila epithelial in vivo model to investigate the interplay between Toll signaling and oncogenic Ras. In the absence of oncogenic Ras (RasV12), Toll signali

SUBMITTER: Brutscher F 

PROVIDER: S-EPMC12036928 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature