Hypothermic Oxygenated Perfusion in Extended Criteria Donor Kidney Transplantation-A Randomized Clinical Trial.

ABSTRACT:

Background

The role of machine perfusion after kidney transplantation (KT) in extended criteria donors (ECD) is unclear, and the current evidence in the literature remains controversial.

Methods

We present an open-label single center randomized trial where 109 patients undergoing KT with ECD grafts between January 2019 and December 2022 were randomized to receive kidneys treated with either hypothermic oxygenated perfusion (HOPE, n = 54) or static cold storage (SCS, n = 55) alone. The primary endpoint was the incidence of delayed graft function (DGF). The secondary endpoints included postoperative complications and graft function and survival in the first year after KT.

Results

The trial failed to meet its primary endpoint. DGF developed in 31 (57%) and 37 (67%) patie

SUBMITTER: Dajti G 

PROVIDER: S-EPMC12036954 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature