Predictors of Incident Heart Failure in Patients With Chronic Chagas Disease Cardiomyopathy.

ABSTRACT:

Purpose

Patients with chronic Chagas cardiomyopathy (CCC) have a high mortality due to heart failure (HF). The aim of this study was to investigate clinical and echocardiographic predictors of incident HF in patients with CCC.

Methods

Single-center retrospective longitudinal observational study which included 176 adult patients (59.1% women; 53.9 ± 10 years old; mean left ventricular [LV] ejection fraction 62% ± 10%) at an early stage of CCC (electrocardiogram and/or wall motion changes but no HF). The primary outcome was incident HF. The association between studied parameters with incident HF was performed by competing-risk survival regression models using the Fine and Gray method.

Results

After a mean follow-up of 8.8 ± 3.6 years, 42 patients progressed to HF (27.04

SUBMITTER: Cunha DMD 

PROVIDER: S-EPMC12036955 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature