The multifaceted roles of the transcriptional coactivator TAZ in extravillous trophoblast development of the human placenta.

ABSTRACT: Insights into the molecular processes that drive early development of the human placenta is crucial for our understanding of pregnancy complications such as preeclampsia and fetal growth restriction, since defects in maturation of its epithelial cell, the trophoblast, have been detected in the severe forms of these diseases. However, key regulators specifying the differentiated trophoblast subtypes of the placenta are only slowly emerging. By using diverse trophoblast cell models, we herein show that the transcriptional coactivator of HIPPO signaling, TAZ, plays a pivotal role in the development of invasive extravillous trophoblasts (EVTs), cells that are essential for decidual vessel remodeling and adaption of maternal blood flow to the placenta. Ribonucleic acid sequencing (RNA-seq) or p

SUBMITTER: Meinhardt G 

PROVIDER: S-EPMC12037006 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature