Receptor kinase pathway signal tuning through a nontranscriptional incoherent feedforward loop.

ABSTRACT: Cellular signaling processes can elicit powerful responses and may need to be amplified to be efficient or dampened to prevent overstimulation. Therefore, they often involve autoregulatory feedbacks. Receptor kinase signaling pathways are abundant in plants, where they convey the presence of both exogenous and endogenous ligands. Among them, endogenous CLAVATA3/EMBRYO SURROUNDING REGION (CLE) peptide signaling acts in an inherently quantitative manner to determine the size of stem cell pools and direct tissue formation. The plant-specific MEMBRANE-ASSOCIATED KINASE REGULATOR (MAKR) family proteins act downstream of receptor kinases. Among the seven family members in Arabidopsis (Arabidopsis thaliana), MAKR5 conveys CLE45 signaling downstream of the receptor kinase BARELY ANY

SUBMITTER: Wang Q 

PROVIDER: S-EPMC12037008 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature