St3gal5-mediated sialylation of glyco-CD177 on neutrophils restricts neuroinflammation following CNS injury.

ABSTRACT: Neutrophils are the most abundant circulating leukocyte population that play critical roles in neuroinflammation following central nervous system (CNS) injury. CD177, a glycoprotein on neutrophils, is emerging as an important immune regulator which can fundamentally affect multiple human inflammatory diseases. However, the role and regulatory mechanism of CD177 glycobiology of neutrophils in neuroinflammation remain elusive. Here, we show that CD177⁺ neutrophils expand significantly and infiltrate the injured brain following CNS injury both in the human and mouse. Using single-cell RNA sequencing and genetic approaches, we find CD177⁺ neutrophils as an anti-inflammatory subset that is critical for modulating neuroinflammation after CNS injury. We further identi

SUBMITTER: Huang T 

PROVIDER: S-EPMC12037025 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature