Mapping global brain reconfigurations following local targeted manipulations.

ABSTRACT: Understanding how localized brain interventions influence whole-brain dynamics is essential for deciphering neural function and designing therapeutic strategies. Using longitudinal functional MRI datasets collected from mice, we investigated the effects of focal interventions, such as thalamic lesions and chemogenetic silencing of cortical hubs. We found that these local manipulations disrupted the brain's ability to sustain network-wide activity, leading to global functional connectivity (FC) reconfigurations. Personalized mouse brain simulations based on experimental data revealed that alterations in local excitability modulate firing rates and frequency content across distributed brain regions, driving these FC changes. Notably, the topography of the affected brain regions depended on t

SUBMITTER: Rabuffo G 

PROVIDER: S-EPMC12037044 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature