Magnetic particle imaging resolution needed for magnetic hyperthermia treatment planning: a sensitivity analysis.

ABSTRACT:

Purpose

Magnetic particle imaging (MPI) is a nascent tracer imaging modality that generates images from magnetic iron oxide nanoparticles (MIONs) in tissue. MPI resolution is a critical input parameter for defining the reliability of simulations-based temperature predictions for magnetic nanoparticle hyperthermia (MNPH). The objective of this study was to ascertain how spatial resolution provided by MPI data affects the reliability of predicted temperatures and thermal dose in simulations using MPI data as inputs.

Methods

Computed tomography (CT) and MPI scans obtained from a tumor injected with MIONs were co-registered to align their coordinates. Co-registered data were used to obtain geometry and volumetric heat sources for computational simulations of MNPH in phantom tumo

SUBMITTER: Pawar S 

PROVIDER: S-EPMC12037136 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature