Validation of a High-Specificity Blood Autoantibody Test to Detect Lung Cancer in Pulmonary Nodules.

ABSTRACT:

Background

Pulmonary nodules (PNs) are frequently detected by chest CT scan, which is increasingly used in clinical practice. Accurately identifying malignant nodules can pose a diagnostic challenge; therefore, a high-specificity biomarker could help clinicians identify malignant nodules and ideally lead to the earlier diagnosis of lung cancer.

Research question

What are the performance characteristics of a blood-based biomarker for identifying malignancy in patients with a CT-detected PN?

Study design and methods

Banked plasma samples from 2 independent prospective observational cohorts of patients presenting with benign or malignant PNs 8 to 30 mm in size were tested using a 7-autoantibody panel. Sensitivity, specificity, and positive predictive value of the autoant

SUBMITTER: Long KJ 

PROVIDER: S-EPMC12037156 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature