Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice.

ABSTRACT: Human immune system (HIS) mice constructed in various ways are widely used for investigations of human immune responses to pathogens, transplants, and immunotherapies. In HIS mice that generate T cells de novo from hematopoietic progenitors, T cell-dependent multisystem autoimmune disease occurs, most rapidly when the human T cells develop in the native NOD.Cg- Prkdcscid Il2rgtm1Wjl (NSG) mouse thymus, where negative selection is abnormal. Disease develops very late when human T cells develop in human fetal thymus grafts, where robust negative selection is observed. We demonstrate here that PD-1⁺CD4⁺ peripheral (Tph) helper-like and follicular (Tfh) helper-like T cells developing in HIS mice can induce autoimmune disease. Tfh-like cells were more promine

SUBMITTER: Khosravi-Maharlooei M 

PROVIDER: S-EPMC12037178 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature