Association between abdominal obesity and cognitive decline among Chinese middle-aged and older adults: a 10-year follow-up from CHARLS.

ABSTRACT:

Introduction

The relationship between abdominal obesity and cognitive decline has controversial results, and the mediating effect of high-density lipoprotein cholesterol (HDL-C) between them remains uncertain. This study aims to explore the association between abdominal obesity and cognitive decline in middle-aged and older adults, including dose-response relationship and age differences, as well as the mediating effect of HDL-C.

Methods

Data were obtained from the China Health and Retirement Longitudinal Study (CHARLS), involving 3,807 participants aged 45 and above from 2010 to 2020. The TICS-10 was used to assess cognitive function, and the group-based trajectory model (GBTM) was used to explore the potential heterogeneity of cognitive changes. Abdominal obesity was measu

SUBMITTER: Wu Q 

PROVIDER: S-EPMC12037387 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature