The TFRC as a prognostic biomarker and potential therapeutic target in cervical cancer: a preliminary study.

ABSTRACT:

Background

Early detection and treatment of CIN or early-stage cervical cancer lead to better clinical outcomes compared to treating advanced-stage patients. Thus, specific biomarkers for the diagnosis and prognosis of CIN and early-stage cervical cancer should be urgently explored.

Methods

We analyzed tumor based on genes closely related to OS in the database with GSE63514, GSE7803, GSE9750 and TCGA data sets, the top 20 core genes were screened out. Notably, transferrin receptor (TFRC) emerged as a prioritized candidate due to its dual role in cellular iron homeostasis and oncogenic signaling. However, the exact role of TFRC in the development and progression of cervical cancer remains unclear. We then used various bioinformatics methods and mathematical models to analyze

SUBMITTER: Wang J 

PROVIDER: S-EPMC12037406 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature