Distinctive seizure signature in the first video case-control study of a naturally-occurring feline autoimmune encephalitis model.

ABSTRACT:

Background and objective

Autoimmune encephalitis (AE) is a form of brain inflammation where pathogenic autoantibodies bind surface proteins. In humans, AE is at least as common as infective encephalitis, and seizures are a prominent manifestation. The most common adult human AE is associated with antibodies to leucine-rich glioma-inactivated 1 (LGI1-Ab-E). AE in non-human mammals is also recognised, notably the polar bear 'Knut', diagnosed with N-methyl D-aspartate receptor antibody encephalitis. LGI1-Ab-E is an emerging cause of spontaneously-arising AE in domestic cats. Our objective was to phenotype the seizure profile of feline LGI1-Ab-E and probe parallels to its human counterpart.

Methods

We characterised seizures in naturally-occurring feline LGI1-Ab-E. Three veterina

SUBMITTER: Binks SNM 

PROVIDER: S-EPMC12037459 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature