Evaluating the effects of coffee consumption on the structure and function of the heart from multiple perspectives.

ABSTRACT:

Objective

To assess the causal relationship between coffee consumption and cardiac structure and function in elderly European populations using multiple genetic methodologies.

Methods

Leveraging genome-wide association study (GWAS) data from elderly European populations, we conducted linkage disequilibrium score regression (LDSC), two-step Mendelian randomization (MR), and colocalization analyses to investigate genetic associations, causal relationships, and mediating effects among these factors. Robustness of findings was verified through comprehensive sensitivity analyses.

Results

LDSC regression analysis revealed positive genetic correlations between coffee consumption and cardiac parameters, excluding left ventricular (LV) ejection fraction and right ventricular (

SUBMITTER: Ma XB 

PROVIDER: S-EPMC12037506 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature