Multi-trait GWAS identifies pleiotropic loci associated with colorectal cancer in East Asian populations.

ABSTRACT:

Introduction

While genome-wide association studies (GWAS) have identified numerous susceptibility loci in Colorectal cancer (CRC), most findings are based on European populations. Additionally, CRC shares genetic architecture with other traits, and multi-trait analysis can improve the discovery of pleiotropic loci.

Materials and methods

We conducted a multi-trait GWAS using the Multi-Trait Analysis of GWAS (MTAG) framework, leveraging large-scale genomic and phenotypic data from BioBank Japan (BBJ). We also examined genetic correlations between CRC and 70 complex traits, followed by local genetic correlation analysis and enrichment of heritability partitioned by chromatin states and tissue types.

Results

We identified 25 genome-wide significant loci for CRC and colon

SUBMITTER: Chen X 

PROVIDER: S-EPMC12037559 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature