Decoding immune cell dynamics in ischemic stroke: insights from single-cell RNA sequencing analysis.

ABSTRACT:

Background

Ischemic stroke (IS) is a leading cause of adult disability worldwide. The inflammatory processes involved are complex, making it challenging to fully understand the pathological mechanisms of IS. Phagocytosis plays an important role in eliminating neurotoxic or damaged neurons resulting from inflammatory responses. This study employed bioinformatics methods to analyze single-cell RNA sequencing (scRNA-seq) data to investigate the cell types and molecular biological processes involved in IS.

Methods

scRNA-seq data for IS were obtained from the Gene Expression Omnibus (GEO). Following sample screening and reprocessing, 5,582 single cells were identified from healthy controls and patients with IS. Uniform manifold approximation and projection (UMAP) was utilized to

SUBMITTER: Lan Y 

PROVIDER: S-EPMC12037566 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature