Changes of brain structure and structural covariance networks in Parkinson's disease with different sides of onset.

ABSTRACT:

Background

Parkinson's disease (PD) typically presents with unilateral symptoms in early stages, starting on one side and progressing, with the onset side showing more severe motor symptoms even after bilateralization. This asymmetry may reflect complex interactions among multiple brain regions and their network connections. In this study, we aimed to use surface-based morphometry (SBM) and structural covariance networks (SCNs) to investigate the differences in brain structure and network characteristics between patients with left-onset PD (LPD) and right-onset PD (RPD).

Methods

A total of 51 LPD and 49 RPD patients were recruited. Clinical assessments included the Unified Parkinson's Disease Rating Scale motor section, Hoehn and Yahr stage, Mini-Mental State Examination, Pa

SUBMITTER: Xu T 

PROVIDER: S-EPMC12037599 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature