Investigating possible shared single nucleotide polymorphisms in isolated oral cleft and non-cleft facial morphology.

ABSTRACT:

Introduction

Facial morphogenesis is regulated by several cellular interactions that are mediated by numerous morphogenetic signals. Based on the existing evidence, we hypothesize that oral cleft-associated single nucleotide polymorphisms (SNPs) are involved in the normal range of human face development. Therefore, this study aimed to investigate the association between SNPs in oral cleft-related genes and variations in the normal range of facial morphology.

Method

A sample of healthy Brazilian teenagers (aged between 11 and 18 years old) were screened and collected. Frontal facial digitized photographs from orthodontic records were used to determine phenotypes, while the DNA extracted from saliva samples was used to investigate the candidate SNPs. Five oral cleft-associated

SUBMITTER: Kuchler EC 

PROVIDER: S-EPMC12037601 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature