Supersulfide controls intestinal inflammation by suppressing CD4⁺ T cell proliferation.

ABSTRACT: Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation where CD4⁺ T lymphocytes play an essential role. Accumulating evidence suggests that immune responses driven by CD4⁺ T cells are critically regulated by various metabolic pathways including oxidative phosphorylation and glycolysis. Here we show that CARS2/CPERS-dependent supersulfide metabolism restrains CD4⁺ T cell proliferation in a cell-intrinsic manner. Under steady state, Cars2 ^+/- mice exhibited spontaneous accumulation of effector/memory CD4⁺ T cells in the colon with age. In lymphopenic conditions, Cars2 ^+/- CD4⁺ T cells showed enhanced cell cycle entry with reduced expression of a cell cycle inhibitor Trp

SUBMITTER: Tayama S 

PROVIDER: S-EPMC12037617 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature