Triglycerides/high-density lipoprotein-cholesterol ratio outperforms traditional lipid indicators in predicting metabolic dysfunction-associated steatotic liver disease among U.S. adults.

ABSTRACT:

Objective

Triglycerides (TG), high-density lipoprotein cholesterol (HDL-c), and their ratio (TG/HDL-c) are key lipid markers associated with metabolic dysfunction. This study aims to investigate the association of TG, HDL-c, and TG/HDL-c ratio with metabolic dysfunction-associated steatotic liver disease (MASLD) and to assess whether TG/HDL-c ratio provides superior predictive ability for MASLD compared to TG or HDL-c alone.

Importance

Although previous research has explored the relationship between TG/HDL-c and MASLD, the applicability of these findings across different ethnicities and populations remains uncertain. Additionally, this study is based on NHANES data, which relies on self-reported measures and lacks longitudinal follow-up, limiting the ability to establish cau

SUBMITTER: Yuan J 

PROVIDER: S-EPMC12037621 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature