Associations Between Pre-Existing Cardiovascular Disease and Survival in Patients on Immune Checkpoint Inhibitor Therapy.

ABSTRACT:

Background

The impact of baseline cardiovascular disease (CVD) on survival in patients undergoing immune checkpoint inhibitor (ICI) therapy is not well understood. Therefore, we sought to determine the relationship between baseline CVD on mortality in patients undergoing ICI monotherapy or combination therapy.

Methods

Using TriNetX, a global database of over 120 million patients, we identified 27,820 patients with pre-existing cardiovascular disease prior to starting ICI monotherapy and an equal number of corresponding matched controls.

Results

Systolic heart failure (HR: 1.38, 95% CI: 1.29-1.48), diastolic heart failure (HR: 1.34, 95% CI: 1.27-1.42), and atrial fibrillation/flutter (HR: 1.24, 95% CI: 1.19-1.29) had the greatest associations with mortality across ICI

SUBMITTER: Mahadevan A 

PROVIDER: S-EPMC12037690 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature