Automated segmentation for cortical thickness of the medial perirhinal cortex.

ABSTRACT: Alzheimer's disease (AD) is characterized by a progressive spread of neurofibrillary tangles (NFT), beginning in the medial perirhinal cortex (mPRC), advancing to the entorhinal cortex (ERC), and subsequently involving the hippocampus, lateral perirhinal cortex (lPRC), and the rest of the brain. Given the close relationship between NFT accumulation and neuronal loss, the mPRC reflects a promising structural marker for early diagnosis of AD. However, only limited tools that automatically measure the cortical thickness of the mPRC are currently available. Utilizing the nnU-Net framework, we trained models on structural MRI of 126 adults, with manually segmented labels as ground truth. These models were then applied to an independent dataset of 103 adults (comprising patients with Alzheimer's

SUBMITTER: Henzen NA 

PROVIDER: S-EPMC12037834 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature