Time-dose reciprocity mechanism for the inactivation of Escherichia coli using X-ray irradiation.

ABSTRACT: The time-dose reciprocity has long been a cornerstone in understanding ultraviolet (UV) sterilization. However, recent studies have demonstrated significant deviations from this law, attributed to complex mechanisms involving reactive oxygen species (ROS). This study investigates whether similar deviations occur at much shorter wavelengths of electromagnetic radiation than UV, specifically in the X-ray region, with a focus on the dose-rate dependence of bacterial inactivation. Using Escherichia coli as a model organism, it is found that dose-rate effects were highly dependent on the bacterial growth phase. In the stationary phase, lower dose rates with prolonged irradiation resulted in greater inactivation efficacy. The inactivation ratio obtained by the dose rate of 15.3 mGy/s shows more

SUBMITTER: Matsumoto T 

PROVIDER: S-EPMC12037914 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature