Synthesis, characterization and bio-evaluation of novel series of pyrazoline derivatives as potential antifungal agents.

ABSTRACT: In this study, a series of novel α, β-unsaturated carbonyl compounds (3a-j) and their pyrazoline derivatives (4a-e and 5a-b) were designed and successfully synthesized. All synthesized compounds were characterized using various spectroscopic techniques, including ¹H NMR, ¹³C NMR, and mass spectrometry. The biological activity of these compounds was evaluated against five bacterial strains (Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus, and Acinetobacter baumannii) and three fungal strains (Candida tropicalis, Candida parapsilosis, and Candida albicans). The results revealed that compound (4c) exhibited potent antifungal activity with a minimum inhibitory concentration (MIC) of 6.25 µg/mL across all tested strains and zone of in

SUBMITTER: Yadav CS 

PROVIDER: S-EPMC12037995 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature