Investigating the association between polyunsaturated fatty acids and osteomyelitis by Mendelian randomization.

ABSTRACT: Osteomyelitis, characterized by bone inflammation and infection, poses a significant global health burden. This Mendelian randomization (MR) study investigates the causal relationship between polyunsaturated fatty acids (PUFAs) and osteomyelitis risk. By using GWAS data from 114,999 individuals, we explore specific PUFAs and their genetic variations using Inverse variance weighted (IVW), MR-Egger and weighted median methods. The results reveal a suggestive association between genetically predicted higher docosahexaenoic acid (DHA) and omega-6 levels with increased osteomyelitis risk. Conversely, a negative association is found for the omega-6:3 ratio. Linoleic acid, omega-3, and omega-6 show no significant associations. Heterogeneity and pleiotropy analyses support result robustness, indic

SUBMITTER: Chen B 

PROVIDER: S-EPMC12037996 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature