High performance thin layer chromatography with eluents containing SDS aided by UV- and Raman spectroscopy.

ABSTRACT: The modification of non-polar silica gel plates by aqueous-organic solvent containing sodium dodecyl sulphate was investigated. The changes that occurred in the sorbent were examined using the Raman spectroscopy technique. The abovementioned technique was also involved in the investigation of carbamazepine-SDS complexes. The approach of applying the Raman spectroscopy into the investigation of the chromatographic behavior of SDS, carbamazepine and RP-18 W sorbent was presented for the first time. The effect of sodium dodecyl sulphate, SDS, concentration on the chosen drug used in neurodegenerative disorder (sulpiride, olanzapine, carbamazepine, trazodone, clomipramine, and pridinol) retention has been investigated. Such examination for these medicines has been presented for the first time

SUBMITTER: Polak B 

PROVIDER: S-EPMC12038010 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature