Stability and robustness of kinetochore dynamics under sudden perturbations and stochastic influences.

ABSTRACT: Understanding the dynamic behavior of kinetochores is crucial for understanding the mechanisms of accurate chromosome segregation during cell division. In this study, we introduced non-linear exponents p and q into two new systems to capture the complex movements that govern the intersister movement of kinetochores during chromosome segregation. Our analysis revealed a power-law relationship between these exponents and the maximum amplitude A of sister kinetochore 2, indicating that even small adjustments in p and q lead to significant changes in kinetochore movement. This sensitivity suggests that kinetochore dynamics are governed by scale-invariant principles, potentially reflecting intrinsic properties of the kinetochore-microtubule interface such as motor protein activity. We observed

SUBMITTER: Mukhamedova F 

PROVIDER: S-EPMC12038042 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature