Microfluidic nanobubbles produced using a micromixer for ultrasound imaging and gene delivery.

ABSTRACT: Ultrasound (US)-mediated delivery is considered relatively safe and achieves tissue-specific targeting by simply adjusting the application site of the physical energy. Moreover, combining US with micro- or nanobubbles (MBs or NBs), which serve as US contrast agents, enhances the delivery of drugs, genes, and nucleic acids which also functioning as a tool for US. The performance of US-responsive MBs and NBs, including their therapeutic outcomes, is influenced by the bubble manufacturing methods. Furthermore, productivity and scalability must also be considered for clinical applications. Among various NBs fabrication techniques, microfluidic technology has emerged as a promising approach. However, the potential of NBs generated by microfluidics for drug delivery remains unexplored. In this s

SUBMITTER: Yamaguchi T 

PROVIDER: S-EPMC12038047 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature