Interaction effects between serum 25(OH)D and CRP status on cancer related mortality in adult cancer survivors.

ABSTRACT: Vitamin D deficiency and elevated CRP (C-reactive protein) levels are independent indicators of risk for mortality in cancer survivors; however, their combined association with mortality has not been examined. This study included adult cancer survivors from four NHANES cycles (2003-2010), utilizing a multistage survey design. CRP levels were measured using a latex-enhanced turbidimetric assay, and serum 25(OH)D levels were assessed using RIA and LC-MS/MS methods. Mortality data were linked with the National Death Index up to 2019. The restricted cubic spline model was used to explore the nonlinear associations with mortality. Kaplan-Meier analysis was used to examine survival curve differences. Cox analysis was employed to assess mortality risk after adjusting for confounding factors, and

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12038049 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature