Differential behavior responses and genetic alteration underpinning exercise effectiveness in stress-susceptible mice.

ABSTRACT: Stress susceptibility varies across individuals, influenced by genetic, molecular, and environmental factors. Hence, approaches for exercise treatment as an antidepressant and anxiolytic intervention must consider individual variability. Examining individual adaptation to exercise provides insights into the biology of such variations. We investigated the efficacy of voluntary wheel running (VWR) exercise as a disease-modifying treatment for stress-susceptible (SS) mice subjected to chronic restraint stress. A multidimensional behavior analysis revealed significant variability in VWR efficacy among individuals; while some mice showed substantial behavior phenotypic improvements (SES), others displayed limited/no benefits (SER). A transcriptomic profiling of the ventral hippocampus, a brain

SUBMITTER: Hwang DJ 

PROVIDER: S-EPMC12038050 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature