H-bonded organic frameworks as ultrasound-programmable delivery platform.

ABSTRACT: The precise control of mechanochemical activation within deep tissues using non-invasive ultrasound holds profound implications for advancing our understanding of fundamental biomedical sciences and revolutionizing disease treatments^1-4. However, a theory-guided mechanoresponsive materials system with well-defined ultrasound activation has yet to be explored^5,6. Here we present the concept of using porous hydrogen-bonded organic frameworks (HOFs) as toolkits for focused ultrasound (FUS) programmably triggered drug activation to control specific cellular events in the deep brain, through on-demand scission of the supramolecular interactions. A theoretical model is developed to potentially visualize the mechanochemical scission and ultrasound mechanics, providing valuab

SUBMITTER: Wang W 

PROVIDER: S-EPMC12038167 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature