Neurological adverse events associated with baclofen: A disproportionality analysis based on FDA Adverse Event Reporting System.

ABSTRACT:

Purpose

Baclofen is a muscle relaxant that could carry the risk for neurological adverse events (nAEs). We aim to analyze the nAE profile of frequently used baclofen for its clinical application.

Methods

Our research is a disproportional analysis based on the FDA Adverse Event Reporting System (FAERS) database. We obtained adverse event reports of baclofen from January 2004 to June 2023 from the FAERS database. Reporting odds ratio (ROR) and Bayesian confidence propagation neural network (BCPNN) were performed to find nAE associated with baclofen.

Results

We extracted a total of 9305 nAE cases with baclofen as the primary suspect. The patients were mostly under 18 years old (45.49%), with markedly more males (43.72%) than females (36.52%). In all, 7275 (78.18%) report

SUBMITTER: Zhang N 

PROVIDER: S-EPMC12038207 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature