Stretch regulation of β2-Adrenoceptor signalling in cardiomyocytes requires caveolae.

ABSTRACT:

Aims

Caveolin-3 is essential for the formation of caveolae in cardiomyocytes. Caveolar microdomains have been shown to regulate the distribution of signalling proteins such as beta-adrenoceptors (βAR) and may act as membrane reserves to protect the cell from damage during the mechanical stretch. Myocardial stretch occurs during haemodynamic overload and may be normal (e.g. exercise) or pathological (e.g. heart failure); therefore, it is important to understand the effect of stretch on signalling pathways associated with mechanosensitive structures, such as caveolae. In this study, we investigate the role of caveolae in regulating the effect of stretch on βAR-signalling.

Methods and results

We used osmotic swelling of isolated rat ventricular cardiomyocytes as a method to str

SUBMITTER: Fu J 

PROVIDER: S-EPMC12038227 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature