Targeted codelivery of nitric oxide and hydrogen sulfide for enhanced antithrombosis efficacy.

ABSTRACT: Thrombosis is a leading cause of mortality worldwide. As important gaseous signaling molecules, both nitric oxide (NO) and hydrogen sulfide (H₂S) demonstrate antiplatelet and anticoagulant functions, but little attention has been given to their synergistic effect and the underlying mechanism. In the present study, we developed an NO/H₂S codelivery system based on enzyme prodrug therapy (EPT) strategy in which the prodrugs are specifically recognized by the engineered β-galactosidase. Targeted codelivery of NO and H₂S in vivo was demonstrated by near-infrared fluorescence imaging and confirmed by measuring plasma and tissue levels; as a result, the side effects caused by systemic delivery, such as bleeding time, were reduced. Delivery of an optimized

SUBMITTER: Deng W 

PROVIDER: S-EPMC12038452 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature