Extended Caffeine for Apnea in Moderately Preterm Infants: The MoCHA Randomized Clinical Trial.

ABSTRACT:

Importance

Hospitalization of moderately preterm infants may be prolonged while waiting for apnea of prematurity to resolve after discontinuing caffeine.

Objective

To evaluate whether extending caffeine treatment reduces the duration of hospitalization.

Design, setting, and participants

From February 2019 to December 2022, this randomized clinical trial in 29 US hospitals enrolled infants born at 29 to 33 weeks' gestation who at 33 to 35 weeks' postmenstrual age were receiving caffeine treatment with plans to discontinue it plus receiving full feeds (≥120 mL/kg/d). Follow-up was completed on March 20, 2023.

Interventions

Infants were randomized to oral caffeine citrate (10 mg/kg/d) or placebo until 28 days after discharge.

Main outcomes and measures

The

SUBMITTER: Carlo WA 

PROVIDER: S-EPMC12038711 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature