Systematic Review and Meta-Analysis of the Association Between Clinical Severity and Co-Infection of Human Adenovirus With Other Respiratory Pathogens in Children.

ABSTRACT: The correlation between the co-infection of human respiratory adenovirus (HAdV) and clinical severity has not been firmly established yet. We carried out a systematic review and meta-analysis. We scoured six databases for studies published up to 16 May 2024. A total of 66 cohort studies, which involved 16 251 participants, were incorporated. When compared with patients suffering from HAdV single infection, those with co-infection of viruses (risk ratios [RRs] = 1.40, 95% confidence interval [CI]: 1.05-1.86), bacteria (RR = 1.50, 95% CI: 1.05-2.16), or fungi (RR = 2.86, 95% CI: 2.17-3.76) were more prone to experience severe clinical outcomes. Co-infection with Mycoplasma pneumoniae had a tendency to elevate the risk of common pneumonia (RR = 1.81, 95% CI: 1.66-1.97), and bacterial co-infec

SUBMITTER: Niu D 

PROVIDER: S-EPMC12038779 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature