Gelatin methacryloyl granular hydrogel scaffolds for skin wound healing.

ABSTRACT: The pore size and structure of hydrogel scaffolds play a key role in regulating host-scaffold interactions. Incorporating macropores within bulk hydrogels may increase cell ingrowth and modulate scaffold-induced inflammation. To this end, granular hydrogel scaffolds (GHS) have been developed via assembling hydrogel microparticles (microgels). GHS have interconnected cell-scale pores, tailored by microgel size, which are readily accessible to cells. Although bulk gelatin methacryloyl (GelMA) hydrogel scaffolds have frequently been used for tissue regeneration, the efficacy of GelMA GHS in wound healing remains unknown. Here, GelMA GHS are fabricated using microfluidic-generated near-uniform microgels to study the effect of macropores on macrophage behavior in vitro, followed b

SUBMITTER: Jaberi A 

PROVIDER: S-EPMC12038805 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature