Flavonoid-Sesquiterpenoid Hybrids from the Leaves of <i>Syzygium simile</i> and Their Anti-Lipid Droplet Accumulation Activities.

ABSTRACT: Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of hepatic disorders characterized by excessive lipid accumulation in the liver with a global prevalence rate of 30%. Despite their increasing prevalence, current therapeutic interventions remain suboptimal, constrained by substantial adverse effects and prohibitive treatment costs. Through an anti-lipid droplet (LD) accumulation screening platform, over 3000 methanolic extracts of Formosan plants were evaluated. Among them, the leaf extract of Syzygium simile demonstrated significant inhibitory activity of 40% at 25 μg/mL, emerging as the most promising species. Through bioassay-guided fractionation, 20 compounds were isolated from the n-hexane layer of the leaves, including nine new compounds [simisyzygi

SUBMITTER: Yang CJ 

PROVIDER: S-EPMC12038841 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature