Gold-catalysed amine synthesis by reductive hydroamination of alkynes with nitroarenes.

ABSTRACT: Amines are the most pivotal class of organic motifs in pharmaceutical compounds. Here we provide a blueprint for a general synthesis of amines by catalyst differentiation enabled by triple Au-H/Au⁺/Au-H relay catalysis. The parent catalyst is differentiated into a set of catalytically active species to enable triple cascade catalysis, where each catalytic species is specifically tuned for one catalytic cycle. This strategy enables the synthesis of biorelevant amine motifs by reductive hydroamination of alkynes with nitroarenes. Using this triple cascade approach, we have achieved exceptional functional group tolerance, enabling the use of bulk chemical feedstocks as coupling partners for the amination of both simple and complex alkynes (>100 examples), including those derived fr

SUBMITTER: Zhou T 

PROVIDER: S-EPMC12038853 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature