Regional and aging-specific cellular architecture of non-human primate brains.

ABSTRACT:

Background

Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain pathogenesis. However, systemic delineation of the cellular composition and molecular connections among multiple brain regions and their alterations induced by aging in NHPs remain largely unresolved.

Methods

In this study, we performed single-nucleus RNA sequencing on 39 samples collected from 10 brain regions of two young and two aged rhesus macaques using the DNBelab C4 system. Validation of protein expression of signatures specific to particular cell types, brain regions, and aging was conducted through a series of immunofluoresce

SUBMITTER: Wang YM 

PROVIDER: S-EPMC12038948 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature