Effect of HPV integration on prognosis of young women with CIN2 in China: protocol for a multicentre prospective cohort study.

ABSTRACT:

Introduction

Cervical cancer, a major global health concern, is primarily caused by human papillomavirus (HPV) infection. Although cervical intraepithelial neoplasia grade 2 (CIN2), a precancerous lesion, exhibits high spontaneous regression rates (50%-60%), particularly in younger women, current clinical management lacks accurate risk stratification. This study examines HPV integration status as a prognostic biomarker in women aged 18-45 diagnosed with CIN2, with the objective of developing a predictive tool for personalised therapeutic strategies and minimising overtreatment in this high-regression population.

Method and analysis

This multicentre cohort study will be implemented across 20 tertiary Grade A hospitals in China, encompassing eastern, western, central and north

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC12039012 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature