Risk analysis of the association between EASIX and all-cause mortality in critical ill patients with atrial fibrillation: a retrospective study from MIMIC-IV database.

ABSTRACT:

Background

The Endothelial Activation and Stress Index (EASIX) is a recognized marker of vascular endothelial health but has limited application in patients with atrial fibrillation (AF). This study aimed to explore the association between EASIX and prognosis in critically ill patients with AF.

Methods

The patient's data were extracted from Medical Information Mart for Intensive Care IV(MIMIC-IV) database. EASIX was calculated as lactate dehydrogenase (U/L) × creatinine (mg/dL)/platelets (10⁹ cells/L) and log2-transformed for statistical analysis. The Boruta algorithm and Least Absolute Shrinkage and Selection Operator (Lasso) Regression were used for feature selection. Multivariable logistic regression and Cox proportional hazard models were employed to assess EA

SUBMITTER: Xia Y 

PROVIDER: S-EPMC12039053 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature